Month: December 2021

SARS-CoV-2 infection and persistence throughout the human body and brain; a pre-peer review article

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has well described pulmonary and extrapulmonary manifestations1-3, including multiorgan failure and shock among severe and fatal cases. Some survivors experience Post-Acute Sequelae of SARS-CoV-2 (PASC) – also known as Long COVID—with cardiovascular, pulmonary, and neurological manifestations with or …

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NIAID issues new awards to fund “pan-coronavirus” vaccines

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, has awarded approximately $36.3 million to three academic institutions to conduct research to develop vaccines to protect against multiple types of coronaviruses and viral variants. The awards are intended to fuel vaccine research for a diverse family of coronaviruses, …

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The Cognitive Load of COVID-19 – Harvard Macy Institute Community Blog

How Does Cognitive Load Theory Relate to COVID-19? Learners in clinical workplaces are at high risk of cognitive overload, and the COVID-19 pandemic compounds this risk. Constantly evolving complex information and changes to workplace practices contribute excessive intrinsic load. Increased demands on time, feelings of uncertainty and anxiety, and negative emotions related to stress introduce …

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SARS-CoV-2 infection and persistence throughout the human body and brain

Abstract COVID-19 is known to cause multi-organ dysfunction1-3 in acute infection, with prolonged symptoms experienced by some patients, termed Post-Acute Sequelae of SARS-CoV-2 (PASC)4-5. However, the burden of infection outside the respiratory tract and time to viral clearance is not well characterized, particularly in the brain3,6-14. We performed complete autopsies on 44 patients with COVID-19 to …

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A Link to the NIH Directors Blog on Preventing Omicron

“There’s been great concern about the new Omicron variant of SARS-CoV-2, the coronavirus that causes COVID-19. A major reason is Omicron has accumulated over 50 mutations, including about 30 in the spike protein, the part of the coronavirus that mRNA vaccines teach our immune systems to attack. All of these genetic changes raise the possibility …

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Early assessment of the clinical severity of the SARS-CoV-2 Omicron variant in South Africa

BackgroundThe SARS-CoV-2 Omicron variant of concern (VOC) almost completely replaced other variants in South Africa during November 2021 and was associated with a rapid increase in COVID-19 cases. We aimed to assess the clinical severity of individuals infected with Omicron, using S Gene Target Failure (SGTF) on the Thermo Fisher Scientific TaqPath COVID-19 PCR test …

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Heart Rate Variability Moderates the Effects of COVID-19-Related Stress and Family Adversity on Emotional Problems in Adolescents: Testing Models of Differential Susceptibility and Diathesis Stress

The COVID-19 pandemic is a unique period of stress, uncertainty, and adversity that will have significant implications for adolescent mental health. Nevertheless, stress and adversity related to COVID-19 may be more consequential for some adolescents’ mental health than for others. We examined whether heart rate variability (HRV) indicated differential susceptibility to mental health difficulties associated …

Heart Rate Variability Moderates the Effects of COVID-19-Related Stress and Family Adversity on Emotional Problems in Adolescents: Testing Models of Differential Susceptibility and Diathesis Stress Read More »

Heart-rate-variability (HRV), predicts outcomes in COVID-19

Background: Patients with COVID-19 present with a variety of clinical manifestations, ranging from mild or asymptomatic disease to severe illness and death. Whilst previous studies have clarified these and several other aspects of COVID-19, one of the ongoing challenges regarding COVID-19 is to determine which patients are at risk of adverse outcomes of COVID-19 infection. …

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Heart Rate Variability in Post-COVID-19 Recovered Subjects

Introduction: A significant proportion of patients recovering from COVID-19 infection experience symptoms attributable to autonomic cardiovascular dysregulation. Heart rate variability (HRV) is a non-invasive marker of cardiovascular dysautonomia. Machine learning (ML) models based on HRV can be used to identify post COVID-19 patients with autonomic dysfunction. Click here to read the entire article Conclusions: A significant …

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SARS-CoV-2 identified by transmission electron microscopy in lymphoproliferative and ischaemic intestinal lesions of COVID-19 patients with acute abdominal pain: two case reports

Abstract Background SARS-CoV-2 may produce intestinal symptoms that are generally mild, with a small percentage of patients developing more severe symptoms. The involvement of SARS-CoV-2 in the physiopathology of bowel damage is poorly known. Transmission electron microscopy (TEM) is a useful tool that provides an understanding of SARS-CoV-2 invasiveness, replication and dissemination in body cells but …

SARS-CoV-2 identified by transmission electron microscopy in lymphoproliferative and ischaemic intestinal lesions of COVID-19 patients with acute abdominal pain: two case reports Read More »

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